How do you deal with severe depression? Try these coping strategies if you're feeling depressed. Stay in touch. Don't withdraw from life. Be more active. Take up some form of exercise. Face your fears. Don't avoid the things you find difficult. Don't drink too much alcohol. For some people, alcohol can become a problem. Try to eat a healthy diet. Have a routine. Why do antidepressants sometimes not work? She said another reason current antidepressants are often ineffective is that they aim to boost neurotransmitters based on the popular molecular explanation of depression, which is that it's the result of decreased levels of the neurotransmitters serotonin, norepinephrine and dopamine.
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